The unfolded protein response in physiological aging and neurovascular degenerative diseases

doi:10.3760/ cma.j.issn.1673-5803.2023.06.017

International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (6): 570-576.doi: 10.3760/ cma.j.issn.1673-5803.2023.06.017

The unfolded protein response in physiological aging and neurovascular degenerative diseases

Jin Yifan, Zou Jiayu, Wu Binrong, Zhang Shaodan

National Clinical Research Center for Ocular Disease, Eye Hospital, Wenzhou Medical University, Wenzhou Zhejiang 325027, China

Received:2023-07-07 Online:2023-12-22 Published:2023-12-22
Contact: Zhang Shaodan, Email: shaodan_zhang @eye.ac.cn
Supported by:
National Natural Science Foundation of China(82070958); Health Science and Technology Program of Zhejiang Province(2021KY811); Innovative Guidance Project of the Eye Hospital of Wenzhou Medical University(YNZD2201903)

Abstract

Abstract: The unfolded protein response (UPR) is a crucial pathway for cells to maintain protein homeostasis. The protein homeostasis of cells will be disrupted, when the internal and external environment of cells is stimulated, such as redox, inflammation or calcium imbalance. Then it will cause protein aggregation or accumulation of abnormal proteins, which further induces endoplasmic reticulum stress, followed by a series of reactions to restore protein homeostasis. If the adaptive UPRs fail to restore protein homeostasis, it will further induce apoptosis. UPR is an important factor affecting physiological and pathological aging, as well as the occurrence and development of neurovascular degenerative diseases.(Int Rev Ophthalmol, 2023, 47： 570-576)

Key words: unfolded protein response, aging, neurovascular degenerative diseases

Jin Yifan, Zou Jiayu, Wu Binrong, Zhang Shaodan. The unfolded protein response in physiological aging and neurovascular degenerative diseases[J]. International Review of Ophthalmology, 2023, 47(6): 570-576.

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The unfolded protein response in physiological aging and neurovascular degenerative diseases

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